Ovarian HistoScanning™ is highly sensitive for the diagnosis of malignant masses

In a European multicentre study, 264 women underwent Ovarian HistoScanning™ prior to surgery for the removal of one or both ovaries. The Ovarian HistoScanning™ results together with the findings from the conventional ultrasound scan and CA 125 were compared with the histological findings. Cancer was considered to be present when invasive or borderline cancerous processes were observed histologically.

In the 375 removed ovaries there were 141 cancers, and 234 non-cancerous ovaries. Of the non-cancerous ovaries 107 were normal and 127 had benign tumours. Ovarian HistoScanning™ correctly identified 138/141 malignant lesions and 206/234 non-malignant tissues (98% sensitivity, 88% specificity). Standard transvaginal ultrasound (TVUS) and CA125 had sensitivities and specificities of 94%/66% and 89%/75%, respectively. Combining standard transvaginal ultrasound and Ovarian HistoScanning™ improved the ultrasound specificity from 66% to 92% (p<0.0001).